prikaz prve stranice dokumenta Expression of Cell Cycle Markers and Proliferation Factors during Human Eye Embryogenesis and Tumorigenesis
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Expression of Cell Cycle Markers and Proliferation Factors during Human Eye Embryogenesis and Tumorigenesis
International Journal of Molecular Sciences, 23 (2022), 16; 9421. https://doi.org/10.3390/ijms23169421
Marin Lovrić, Josipa; Filipović, Natalija; Znaor, Ljubo; Rančić, Anita; Petričević, Joško; Kunac, Nenad; Šoljić, Violeta; Saraga-Babić, Mirna; Vukojević, Katarina

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Marin Lovrić, J., Filipović, N., Znaor, Lj., Rančić, A., Petričević, J., Kunac, N. ... Vukojević, K. (2022). Expression of Cell Cycle Markers and Proliferation Factors during Human Eye Embryogenesis and Tumorigenesis. International Journal of Molecular Sciences, 23. (16). doi: 10.3390/ijms23169421

Marin Lovrić, Josipa, et al. "Expression of Cell Cycle Markers and Proliferation Factors during Human Eye Embryogenesis and Tumorigenesis." International Journal of Molecular Sciences, vol. 23, br. 16, 2022. https://doi.org/10.3390/ijms23169421

Marin Lovrić, Josipa, Natalija Filipović, Ljubo Znaor, Anita Rančić, Joško Petričević, Nenad Kunac, Violeta Šoljić, Mirna Saraga Babić i Katarina Vukojević. "Expression of Cell Cycle Markers and Proliferation Factors during Human Eye Embryogenesis and Tumorigenesis." International Journal of Molecular Sciences 23, br. 16 (2022). https://doi.org/10.3390/ijms23169421

Marin Lovrić, J., et al. (2022) 'Expression of Cell Cycle Markers and Proliferation Factors during Human Eye Embryogenesis and Tumorigenesis', International Journal of Molecular Sciences, 23(16). doi: 10.3390/ijms23169421

Marin Lovrić J, Filipović N, Znaor Lj, Rančić A, Petričević J, Kunac N, i sur.. Expression of Cell Cycle Markers and Proliferation Factors during Human Eye Embryogenesis and Tumorigenesis. International Journal of Molecular Sciences [Internet]. 2022. [pristupljeno 15.11.2024.];23(16). doi: 10.3390/ijms23169421

J. Marin Lovrić, et al., "Expression of Cell Cycle Markers and Proliferation Factors during Human Eye Embryogenesis and Tumorigenesis", International Journal of Molecular Sciences, vol. 23, br. 16, 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:266:073472. [Citirano: 15.11.2024.]

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Naslov (engleski)Expression of Cell Cycle Markers and Proliferation Factors during Human Eye Embryogenesis and Tumorigenesis
AutorJosipa Marin Lovrić
AutorNatalija Filipović https://orcid.org/0000-0002-8943-4109
AutorLjubo Znaor
AutorAnita Rančić
AutorJoško Petričević https://orcid.org/0000-0003-1997-852X
AutorNenad Kunac
AutorVioleta Šoljić
AutorMirna Saraga-Babić
AutorKatarina Vukojević https://orcid.org/0000-0003-2182-2890
Autorova ustanova(Klinički bolnički centar Split)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Medicinska biokemija
Sažetak (engleski)
The expression pattern of the markers p19, Ki-67, MSX1, MSX2, PDL1, pRB, and CYCLINA2 was quantitatively and semiquantitatively analyzed in histologic sections of the developing and postnatal human eye at week 8, in retinoblastoma, and in various uveal melanomas post hoc studies by double immunofluorescence. The p19 immunoreactivity characterized retinal and/or choroidal cells in healthy and tumor tissues: expression was lower in the postnatal retina than in the developing retina and retinoblastoma, whereas it was high in epithelioid melanomas. Ki67 expression was high in the developing eye, retinoblastoma, and choroidal melanomas. MSX1 and MSX2 expression was similar in the developing eye and retinoblastoma, whereas it was absent in the postnatal eye. Their different expression was evident between epithelioid and myxoid melanomas. Similarly, PDL1 was absent in epithelioid melanomas, whereas it was highly expressed in developing and tumor tissues. Expression of pRB and CYCA2 was characteristic of developing and tumorous eye samples but not of the healthy postnatal eye. The observed expression differences of the analyzed markers correlate with the origin and stage of cell differentiation of the tissue samples. The fine balance of expression could play a role in both human eye development and ocular tumorigenesis. Therefore, understanding their relationship and interplay could open new avenues for potential therapeutic interventions and a better understanding of the mechanisms underlying the developmental plasticity of the eye and the development of neoplasms.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 23, br. 16, 9421
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms23169421
URN:NBNurn:nbn:hr:266:073472
Datum objave publikacije2022
URL dokumentahttps://www.mdpi.com/1422-0067/23/16/9421/pdf?version=1661319826
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-09-08 16:04:26