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Methods Used for Enhancing the Bioavailability of Oral Curcumin in Randomized Controlled Trials : A Meta-Research Study
Pharmaceuticals, 15 (2022), 8; 939. https://doi.org/10.3390/ph15080939
Mimica, Bruna; Bučevic Popović, Viljemka; Banjari, Ines; Jeličić Kadić, Antonia; Puljak, Livia

Citirajte ovaj rad

Mimica, B., Bučevic Popović, V., Banjari, I., Jeličić Kadić, A. i Puljak, L. (2022). Methods Used for Enhancing the Bioavailability of Oral Curcumin in Randomized Controlled Trials : A Meta-Research Study. Pharmaceuticals, 15. (8). doi: 10.3390/ph15080939

Mimica, Bruna, et al. "Methods Used for Enhancing the Bioavailability of Oral Curcumin in Randomized Controlled Trials : A Meta-Research Study." Pharmaceuticals, vol. 15, br. 8, 2022. https://doi.org/10.3390/ph15080939

Mimica, Bruna, Viljemka Bučevic Popović, Ines Banjari, Antonia Jeličić Kadić i Livia Puljak. "Methods Used for Enhancing the Bioavailability of Oral Curcumin in Randomized Controlled Trials : A Meta-Research Study." Pharmaceuticals 15, br. 8 (2022). https://doi.org/10.3390/ph15080939

Mimica, B., et al. (2022) 'Methods Used for Enhancing the Bioavailability of Oral Curcumin in Randomized Controlled Trials : A Meta-Research Study', Pharmaceuticals, 15(8). doi: 10.3390/ph15080939

Mimica B, Bučevic Popović V, Banjari I, Jeličić Kadić A, Puljak L. Methods Used for Enhancing the Bioavailability of Oral Curcumin in Randomized Controlled Trials : A Meta-Research Study. Pharmaceuticals [Internet]. 2022. [pristupljeno 13.04.2024.];15(8). doi: 10.3390/ph15080939

B. Mimica, V. Bučevic Popović, I. Banjari, A. Jeličić Kadić i L. Puljak, "Methods Used for Enhancing the Bioavailability of Oral Curcumin in Randomized Controlled Trials : A Meta-Research Study", Pharmaceuticals, vol. 15, br. 8, 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:266:510274. [Citirano: 13.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:266:510274
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Podaci o radu
Naslov (engleski)Methods Used for Enhancing the Bioavailability of Oral Curcumin in Randomized Controlled Trials : A Meta-Research Study
AutorBruna Mimica https://orcid.org/0000-0001-9708-0673
AutorViljemka Bučevic Popović https://orcid.org/0000-0001-9927-1107
AutorInes Banjari https://orcid.org/0000-0002-8680-5007
AutorAntonia Jeličić Kadić https://orcid.org/0000-0002-1873-960X
AutorLivia Puljak
Autorova ustanova(Klinički bolnički centar Split)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Farmacija
Farmacija
Sažetak (engleski)
It is unknown how randomized controlled trials (RCTs) approach the problem related to curcumin bioavailability. We analyzed methods and reporting regarding the bioavailability of systemic oral curcumin used in RCTs. We searched PubMed on 12 September 2020, to find articles reporting RCTs that used curcumin as an intervention. We extracted data about trial characteristics, curcumin products used, methods for improving curcumin bioavailability, and mentions of curcumin bioavailability. We included 165 RCTs. The most common category of intervention was simply described as "curcumin" or "curcuminoids" without a commercial name. There were 107 (64%) manuscripts that reported that they used methods to enhance the oral bioavailability of curcuminoids used in their intervention; 25 different methods were reported. The most common method was the addition of piperine (23%). Phospholipidated curcumin, a combination of curcumin and turmeric oils, nanomicellar curcumin, and colloidal dispersion of curcumin were the next most common methods. Fourteen trials (8.4%) compared more than one different curcumin product; nine (7.9%) trials compared the bioavailability/pharmacokinetics of curcumin products. In conclusion, a high number of diverse methods were used, and very few trials compared different curcumin products. More studies are needed to explore the comparative bioavailability and efficacy of different curcumin products.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPharmaceuticals
Brojčani podacivol. 15, br. 8, 939
e-ISSN1424-8247
DOIhttps://doi.org/10.3390/ph15080939
URN:NBNurn:nbn:hr:266:510274
Datum objave publikacije2022
URL dokumentahttps://www.mdpi.com/1424-8247/15/8/939/pdf?version=1659695522
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-09-08 13:20:53