prikaz prve stranice dokumenta Expression of Cell Cycle Markers and Proliferation Factors during Human Eye Embryogenesis and Tumorigenesis
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Scientific paper - Original scientific paper
Expression of Cell Cycle Markers and Proliferation Factors during Human Eye Embryogenesis and Tumorigenesis
International Journal of Molecular Sciences, 23 (2022), 16; 9421. https://doi.org/10.3390/ijms23169421
Marin Lovrić, Josipa; Filipović, Natalija; Znaor, Ljubo; Rančić, Anita; Petričević, Joško; Kunac, Nenad; Šoljić, Violeta; Saraga-Babić, Mirna; Vukojević, Katarina

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Marin Lovrić, J., Filipović, N., Znaor, Lj., Rančić, A., Petričević, J., Kunac, N. ... Vukojević, K. (2022). Expression of Cell Cycle Markers and Proliferation Factors during Human Eye Embryogenesis and Tumorigenesis. International Journal of Molecular Sciences, 23. (16). doi: 10.3390/ijms23169421

Marin Lovrić, Josipa, et al. "Expression of Cell Cycle Markers and Proliferation Factors during Human Eye Embryogenesis and Tumorigenesis." International Journal of Molecular Sciences, vol. 23, no. 16, 2022. https://doi.org/10.3390/ijms23169421

Marin Lovrić, Josipa, Natalija Filipović, Ljubo Znaor, Anita Rančić, Joško Petričević, Nenad Kunac, Violeta Šoljić, Mirna Saraga Babić and Katarina Vukojević. "Expression of Cell Cycle Markers and Proliferation Factors during Human Eye Embryogenesis and Tumorigenesis." International Journal of Molecular Sciences 23, no. 16 (2022). https://doi.org/10.3390/ijms23169421

Marin Lovrić, J., et al. (2022) 'Expression of Cell Cycle Markers and Proliferation Factors during Human Eye Embryogenesis and Tumorigenesis', International Journal of Molecular Sciences, 23(16). doi: 10.3390/ijms23169421

Marin Lovrić J, Filipović N, Znaor Lj, Rančić A, Petričević J, Kunac N, and sur.. Expression of Cell Cycle Markers and Proliferation Factors during Human Eye Embryogenesis and Tumorigenesis. International Journal of Molecular Sciences [Internet]. 2022 [cited 2024 December 18];23(16). doi: 10.3390/ijms23169421

J. Marin Lovrić, et al., "Expression of Cell Cycle Markers and Proliferation Factors during Human Eye Embryogenesis and Tumorigenesis", International Journal of Molecular Sciences, vol. 23, no. 16, 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:266:073472. [Accessed: 18 December 2024]

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Metadata
Title (english)Expression of Cell Cycle Markers and Proliferation Factors during Human Eye Embryogenesis and Tumorigenesis
AuthorJosipa Marin Lovrić
AuthorNatalija Filipović https://orcid.org/0000-0002-8943-4109
AuthorLjubo Znaor
AuthorAnita Rančić
AuthorJoško Petričević https://orcid.org/0000-0003-1997-852X
AuthorNenad Kunac
AuthorVioleta Šoljić
AuthorMirna Saraga-Babić
AuthorKatarina Vukojević https://orcid.org/0000-0003-2182-2890
Author's institution(University Hospital of Split)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Medical Biochemistry
Abstract (english)
The expression pattern of the markers p19, Ki-67, MSX1, MSX2, PDL1, pRB, and CYCLINA2 was quantitatively and semiquantitatively analyzed in histologic sections of the developing and postnatal human eye at week 8, in retinoblastoma, and in various uveal melanomas post hoc studies by double immunofluorescence. The p19 immunoreactivity characterized retinal and/or choroidal cells in healthy and tumor tissues: expression was lower in the postnatal retina than in the developing retina and retinoblastoma, whereas it was high in epithelioid melanomas. Ki67 expression was high in the developing eye, retinoblastoma, and choroidal melanomas. MSX1 and MSX2 expression was similar in the developing eye and retinoblastoma, whereas it was absent in the postnatal eye. Their different expression was evident between epithelioid and myxoid melanomas. Similarly, PDL1 was absent in epithelioid melanomas, whereas it was highly expressed in developing and tumor tissues. Expression of pRB and CYCA2 was characteristic of developing and tumorous eye samples but not of the healthy postnatal eye. The observed expression differences of the analyzed markers correlate with the origin and stage of cell differentiation of the tissue samples. The fine balance of expression could play a role in both human eye development and ocular tumorigenesis. Therefore, understanding their relationship and interplay could open new avenues for potential therapeutic interventions and a better understanding of the mechanisms underlying the developmental plasticity of the eye and the development of neoplasms.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleInternational Journal of Molecular Sciences
Numberingvol. 23, no. 16, 9421
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms23169421
URN:NBNurn:nbn:hr:266:073472
Publication2022
Document URLhttps://www.mdpi.com/1422-0067/23/16/9421/pdf?version=1661319826
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-09-08 16:04:26